Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615080 | 0.74 | KDM4E (0.38) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL13291390 | 0.65 | CES2 (0.74) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL8176735 | 0.62 | ALB (0.55) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL9231816 | 0.61 | CES2 (0.43) | MAPK14CES2CES1KDM4EKMT2A | |
| SCHEMBL8864704 | 0.60 | ALDH1A1 (0.55) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL19519478 | 0.59 | CES2 (0.53) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL11217545 | 0.59 | CES2 (0.53) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL28305668 | 0.59 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL10627251 | 0.58 | EGFR (0.52) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL8182920 | 0.57 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149096-B1 | TRICYCLIC PYRIDINE N-OXIDES VASOPRESSIN AGONISTS | WYETH CORP (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6235900-B1 | Tricyclic pyridine N-oxides vasopressin agonists | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-22 | — | — | US | disclosed |