Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.57 |
| ▸ | NAMPT | P43490 | 4/20 | 0.56 |
| ▸ | ABCC9 | O60706 | 8/20 | 0.53 |
| ▸ | KCNJ11 | Q14654 | 8/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 6/20 | 0.53 |
| ▸ | KCNJ8 | Q15842 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682845 | 0.90 | CYP11B1 (0.59) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL4682843 | 0.90 | CYP11B1 (0.59) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL7742276 | 0.86 | ABCC9 (0.56) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL6614997 | 0.86 | ABCC9 (0.52) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL7742284 | 0.86 | ABCC9 (0.54) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL7741529 | 0.85 | ABCC9 (0.58) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL810378 | 0.84 | IKBKB (0.56) | NAMPTKMT2AMAPK1 | |
| SCHEMBL6641546 | 0.82 | ABCC9 (0.53) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL6647532 | 0.82 | ABCC9 (0.54) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 | |
| SCHEMBL6611583 | 0.81 | ABCC9 (0.54) | CYP11B1CYP11B2NAMPTABCC9KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | claimed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |