Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.40 |
| ▸ | GIPR | P48546 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 9/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617662 | 0.84 | GCGR (0.39) | GCGRGIPRABL1TRPV1AURKA | |
| SCHEMBL6615941 | 0.83 | GCGR (0.37) | GCGRGIPRABL1TRPV1MAPT | |
| SCHEMBL6617186 | 0.79 | GCGR (0.44) | GCGRGIPRABL1TRPV1HRH3 | |
| SCHEMBL6616710 | 0.78 | ABL1 (0.35) | GCGRGIPRABL1TRPV1 | |
| SCHEMBL6619833 | 0.78 | TRPV1 (0.43) | GCGRGIPRABL1TRPV1 | |
| SCHEMBL6616488 | 0.77 | GCGR (0.43) | GCGRGIPRABL1TRPV1AURKA | |
| SCHEMBL6619980 | 0.77 | GCGR (0.45) | GCGRGIPRABL1NPC1RAB9A | |
| SCHEMBL6615997 | 0.77 | GCGR (0.45) | GCGRGIPRABL1TRPV1HRH3 | |
| SCHEMBL6616880 | 0.77 | MEN1 (0.43) | TRPV1MAPTNPC1RAB9A | |
| SCHEMBL6616422 | 0.76 | NAMPT (0.45) | GCGRGIPRABL1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |