Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.37 |
| ▸ | GIPR | P48546 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 10/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617918 | 0.85 | NAMPT (0.39) | GCGRGIPRABL1DDR1DDR2 | |
| SCHEMBL6616710 | 0.85 | ABL1 (0.35) | GCGRGIPRABL1TRPV1DDR1 | |
| SCHEMBL6615303 | 0.83 | GCGR (0.40) | GCGRGIPRABL1TRPV1MAPT | |
| SCHEMBL6617017 | 0.80 | KMT2A (0.44) | MAPT | |
| SCHEMBL6617914 | 0.79 | KMT2A (0.47) | MAPT | |
| SCHEMBL6614050 | 0.79 | GCGR (0.43) | GCGRGIPRABL1TRPV1 | |
| SCHEMBL6615591 | 0.79 | RAB9A (0.39) | MAPTMCHR1 | |
| SCHEMBL6617661 | 0.78 | GCGR (0.41) | GCGRGIPRABL1MAPT | |
| SCHEMBL6616663 | 0.78 | RAB9A (0.39) | MAPTMCHR1 | |
| SCHEMBL6617186 | 0.77 | GCGR (0.44) | GCGRGIPRABL1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |