Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.44 |
| ▸ | GIPR | P48546 | 4/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 6/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615259 | 0.88 | MEN1 (0.40) | TRPV1NAMPTNPC1RAB9A | |
| SCHEMBL6616697 | 0.86 | KMT2A (0.44) | NPC1RAB9A | |
| SCHEMBL6615959 | 0.85 | P2RY14 (0.41) | NAMPTNPC1RAB9A | |
| SCHEMBL6615338 | 0.84 | RAF1 (0.44) | RAB9A | |
| SCHEMBL6615997 | 0.83 | GCGR (0.45) | GCGRGIPRTRPV1ABL1NAMPT | |
| SCHEMBL6619980 | 0.83 | GCGR (0.45) | GCGRGIPRABL1NAMPTNPC1 | |
| SCHEMBL6616422 | 0.82 | NAMPT (0.45) | GCGRGIPRTRPV1ABL1NAMPT | |
| SCHEMBL6616710 | 0.82 | ABL1 (0.35) | GCGRGIPRTRPV1ABL1NAMPT | |
| SCHEMBL6615051 | 0.82 | SCN2A (0.42) | GCGRGIPRTRPV1ABL1NAMPT | |
| SCHEMBL6604618 | 0.82 | RAB9A (0.40) | TRPV1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |