Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616089 | 0.90 | ALDH1A1 (0.43) | MAPTSMN1; SMN2KDM4CACKR3ALDH1A1 | |
| SCHEMBL6603258 | 0.88 | ALDH1A1 (0.44) | MAPTSMN1; SMN2KDM4CACKR3ALDH1A1 | |
| SCHEMBL6620553 | 0.88 | RAB9A (0.42) | KDM4CACKR3ALDH1A1KDM4ELMNA | |
| SCHEMBL6661397 | 0.86 | CRACR2A (0.45) | MAPTSMN1; SMN2KDM4CACKR3ALDH1A1 | |
| SCHEMBL6619112 | 0.86 | ALDH1A1 (0.42) | MAPTSMN1; SMN2KDM4CACKR3ALDH1A1 | |
| SCHEMBL6618827 | 0.86 | ACKR3 (0.40) | MAPTSMN1; SMN2ACKR3ALDH1A1MEN1 | |
| SCHEMBL6613151 | 0.86 | ALDH1A1 (0.41) | MAPTSMN1; SMN2ACKR3ALDH1A1MEN1 | |
| SCHEMBL6616043 | 0.85 | MAPT (0.43) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6614830 | 0.85 | MAPT (0.41) | MAPTSMN1; SMN2KDM4CALDH1A1MEN1 | |
| SCHEMBL6622540 | 0.84 | RAB9A (0.44) | MAPTSMN1; SMN2ACKR3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |