Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620553 | 0.89 | RAB9A (0.42) | ALDH1A1POLBACKR3KDM4CHPGD | |
| SCHEMBL6618475 | 0.89 | RAB9A (0.42) | ALDH1A1POLBSMN1; SMN2MAPTKDM4C | |
| SCHEMBL6615270 | 0.88 | CRACR2A (0.44) | CRACR2AALDH1A1SMN1; SMN2MAPTACKR3 | |
| SCHEMBL6616751 | 0.88 | CRACR2A (0.45) | CRACR2AAVPR2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6620003 | 0.87 | RAB9A (0.39) | CRACR2AALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL6621561 | 0.87 | SMN1; SMN2 (0.40) | ALDH1A1POLBSMN1; SMN2MAPTACKR3 | |
| SCHEMBL6616043 | 0.87 | MAPT (0.43) | ALDH1A1POLBSMN1; SMN2MAPTMEN1 | |
| SCHEMBL6615419 | 0.86 | MAPT (0.40) | ALDH1A1SMN1; SMN2MAPTACKR3KDM4C | |
| SCHEMBL6622540 | 0.86 | RAB9A (0.44) | ALDH1A1POLBSMN1; SMN2MAPTACKR3 | |
| SCHEMBL6615757 | 0.85 | KDM4C (0.40) | CRACR2AALDH1A1POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |