Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615423 | 0.83 | PTGDR2 (0.47) | PTGDR2PTGDRPTGER2L3MBTL1SLC6A2 | |
| SCHEMBL5884573 | 0.79 | PTGDR2 (0.49) | PTGDR2PTGDRPTGER2SLC6A2SLC6A4 | |
| SCHEMBL22453733 | 0.73 | LMNA (0.39) | PTGDR2PTGDRL3MBTL1KDM4EHTT | |
| SCHEMBL3545617 | 0.73 | PTGDR2 (0.51) | PTGDR2PTGDRPTGER2KDM4EHTT | |
| SCHEMBL14640344 | 0.71 | PTGDR2 (0.62) | PTGDR2PTGDRPTGER2L3MBTL1KMT2A | |
| SCHEMBL11174850 | 0.70 | PTGDR2 (0.54) | PTGDR2PTGDRPTGER2KDM4EKMT2A | |
| SCHEMBL11479776 | 0.70 | PTGDR2 (0.68) | PTGDR2PTGDRPTGER2SLC6A2SLC6A4 | |
| SCHEMBL5182802 | 0.70 | KDM4E (0.50) | L3MBTL1KDM4EGLAHTTKMT2A | |
| SCHEMBL11174525 | 0.69 | PTGDR2 (0.53) | PTGDR2PTGDRPTGER2KDM4EKMT2A | |
| SCHEMBL16475192 | 0.68 | PDGFRB (0.47) | L3MBTL1KDM4EGLAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418916-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |