Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.49 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615428 | 0.79 | PTGDR2 (0.51) | PTGDR2PTGDRPTGER2GCGRSLC6A4 | |
| SCHEMBL2903205 | 0.77 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3ALDH1A1HPGD | |
| SCHEMBL6615423 | 0.75 | PTGDR2 (0.47) | PTGDR2PTGDRPTGER2GCGRSLC6A4 | |
| SCHEMBL2901099 | 0.74 | LMNA (0.41) | SLC6A4ALDH1A1TSHR | |
| SCHEMBL2897675 | 0.72 | SLC22A12 (0.41) | ALDH1A1HPGD | |
| SCHEMBL14640344 | 0.70 | PTGDR2 (0.62) | PTGDR2PTGDRPTGER2HTR2CHPGD | |
| SCHEMBL3545617 | 0.69 | PTGDR2 (0.51) | PTGDR2PTGDRPTGER2SLC6A4SLC6A2 | |
| SCHEMBL11174850 | 0.69 | PTGDR2 (0.54) | PTGDR2PTGDRPTGER2HTR2CHTR2B | |
| SCHEMBL10392932 | 0.69 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3ALDH1A1HPGD | |
| SCHEMBL11174525 | 0.68 | PTGDR2 (0.53) | PTGDR2PTGDRPTGER2SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115617-B2 | Amino-substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |