Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620400 | 0.91 | AAK1 (0.41) | ALDH1A1KDM4EHPGDRAB9ANPC1 | |
| SCHEMBL6616869 | 0.88 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6617639 | 0.86 | RAB9A (0.41) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6618565 | 0.86 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6616939 | 0.85 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDRAB9ANPC1 | |
| SCHEMBL6609241 | 0.85 | KMT2A (0.45) | MEN1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6614370 | 0.85 | KMT2A (0.45) | MEN1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6604618 | 0.85 | RAB9A (0.40) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL6616543 | 0.85 | KMT2A (0.42) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6619728 | 0.85 | AAK1 (0.41) | ALDH1A1KDM4EHPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |