Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616031 | 0.97 | RAB9A (0.40) | RAB9ANPC1MAPTACKR3TP53 | |
| SCHEMBL6615591 | 0.92 | RAB9A (0.39) | RAB9ANPC1MAPTACKR3TP53 | |
| SCHEMBL6618133 | 0.89 | RAB9A (0.41) | RAB9ANPC1MAPTTP53THRB | |
| SCHEMBL6617319 | 0.88 | RAB9A (0.40) | RAB9ANPC1MAPTTP53THRB | |
| SCHEMBL6621127 | 0.86 | MEN1 (0.41) | RAB9ANPC1MAPTTP53LMNA | |
| SCHEMBL6617672 | 0.85 | CRACR2A (0.47) | RAB9AMAPTACKR3TP53CRACR2A | |
| SCHEMBL6615863 | 0.85 | RAB9A (0.40) | RAB9ANPC1MAPTTP53THRB | |
| SCHEMBL6614537 | 0.85 | ACKR3 (0.41) | RAB9ANPC1MAPTACKR3TP53 | |
| SCHEMBL6615512 | 0.85 | ALDH1A1 (0.43) | RAB9ANPC1MAPTCRACR2AKDM4E | |
| SCHEMBL6618316 | 0.84 | MAPT (0.42) | RAB9AMAPTTP53CRACR2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |