Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 7/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.61 |
| ▸ | IDH1 | O75874 | 5/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616432 | 0.83 | AVPR2 (0.53) | AVPR2AVPR1AIDH1P2RX7PARP1 | |
| SCHEMBL7451415 | 0.81 | AVPR2 (0.39) | AVPR2AVPR1AIDH1NTRK1DYRK1A | |
| SCHEMBL7510097 | 0.81 | AVPR2 (0.41) | AVPR2AVPR1APAK1RORB | |
| SCHEMBL7508188 | 0.81 | IDH1 (0.39) | AVPR2AVPR1AIDH1NTRK1DYRK1A | |
| SCHEMBL7323380 | 0.76 | AVPR2 (1.00) | AVPR2AVPR1AIDH1 | |
| SCHEMBL6615080 | 0.73 | KDM4E (0.38) | AVPR2IDH1 | |
| SCHEMBL7505774 | 0.72 | P2RX3 (0.34) | AVPR2AVPR1AIDH1 | |
| SCHEMBL6616672 | 0.72 | AVPR2 (0.49) | AVPR2AVPR1AIDH1 | |
| SCHEMBL6616850 | 0.72 | AVPR2 (0.62) | AVPR2AVPR1AIDH1 | |
| SCHEMBL7395315 | 0.71 | BRD4 (0.39) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000059-B1 | TRICYCLIC VASOPRESSIN AGONISTS | WYETH CORP (US) | 2004-09-29 | — | — | EP | claimed |
| US-6194407-B1 | INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION | 2001-02-27 | — | — | US | claimed |
| EP-1000059-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-17 | — | — | EP | claimed |
| WO-1999006403-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-11 | — | — | WO | claimed |
| EP-1000059-B1 | TRICYCLIC VASOPRESSIN AGONISTS | WYETH CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1149096-B1 | TRICYCLIC PYRIDINE N-OXIDES VASOPRESSIN AGONISTS | WYETH CORP (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-1149096-A2 | TRICYCLIC PYRIDINE N-OXIDES VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-31 | — | — | EP | disclosed |
| US-6235900-B1 | Tricyclic pyridine N-oxides vasopressin agonists | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-22 | — | — | US | disclosed |
| US-6194407-B1 | INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION | 2001-02-27 | — | — | US | disclosed |
| WO-2000046224-A2 | TRICYCLIC PYRIDINE N-OXIDES VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-10 | — | — | WO | disclosed |
| US-6090803-A | ANTIDIABETIC AGENTS; INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0309043-A2 | Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-29 | — | — | EP | disclosed |