Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.42 |
| ▸ | GCGR | P47871 | 4/20 | 0.42 |
| ▸ | GIPR | P48546 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DDT | P30046 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615997 | 0.92 | GCGR (0.45) | NAMPTGCGRGIPRABL1NR1H4 | |
| SCHEMBL6616244 | 0.90 | NAMPT (0.41) | NAMPTNPC1RAB9ADDTNR1H4 | |
| SCHEMBL6616488 | 0.89 | GCGR (0.43) | NAMPTGCGRGIPRAURKARPS6KB1 | |
| SCHEMBL6619980 | 0.89 | GCGR (0.45) | NAMPTGCGRGIPRNPC1RAB9A | |
| SCHEMBL6623315 | 0.89 | KCNK3 (0.43) | NAMPTNPC1RAB9ADDTNR1H4 | |
| SCHEMBL6616422 | 0.88 | NAMPT (0.45) | NAMPTGCGRGIPRABL1NR1H4 | |
| SCHEMBL6615051 | 0.88 | SCN2A (0.42) | NAMPTGCGRGIPRNPC1RAB9A | |
| SCHEMBL6615889 | 0.88 | TRPV1 (0.45) | NAMPTGCGRGIPRABL1EPHX2 | |
| SCHEMBL6673259 | 0.87 | NAMPT (0.41) | NAMPTRAB9ADDTNR1H4MAPK14 | |
| SCHEMBL6616574 | 0.86 | NR1H4 (0.42) | NAMPTNPC1RAB9AAURKANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |