Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | GIPR | P48546 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 5/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613041 | 0.91 | TRPV1 (0.44) | TRPV1GCGRNAMPTGIPRABL1 | |
| SCHEMBL6619833 | 0.89 | TRPV1 (0.43) | TRPV1GCGRNAMPTGIPRABL1 | |
| SCHEMBL6618867 | 0.89 | TP53 (0.41) | TRPV1NAMPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6617061 | 0.89 | TAOK1 (0.42) | NAMPTABL1MCHR1LMNANPC1 | |
| SCHEMBL6615997 | 0.88 | GCGR (0.45) | TRPV1GCGRNAMPTGIPRABL1 | |
| SCHEMBL6615756 | 0.88 | NAMPT (0.42) | GCGRNAMPTGIPRABL1NPC1 | |
| SCHEMBL6619980 | 0.87 | GCGR (0.45) | GCGRNAMPTGIPRABL1NPC1 | |
| SCHEMBL6619665 | 0.86 | P2RY14 (0.41) | NAMPTNPC1RAB9AMAPT | |
| SCHEMBL6616422 | 0.86 | NAMPT (0.45) | TRPV1GCGRNAMPTGIPRABL1 | |
| SCHEMBL6615889 | 0.84 | TRPV1 (0.45) | TRPV1GCGRNAMPTGIPRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |