Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DDT | P30046 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614537 | 0.92 | ACKR3 (0.41) | MAPTRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL6623315 | 0.91 | KCNK3 (0.43) | NAMPTMAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6673259 | 0.91 | NAMPT (0.41) | NAMPTMAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6615756 | 0.90 | NAMPT (0.42) | NAMPTRAB9ADDTNPC1NR1H4 | |
| SCHEMBL6618316 | 0.88 | MAPT (0.42) | NAMPTMAPTRAB9AALDH1A1TP53 | |
| SCHEMBL6618133 | 0.87 | RAB9A (0.41) | MAPTRAB9AKDM4EMEN1KMT2A | |
| SCHEMBL6617061 | 0.87 | TAOK1 (0.42) | NAMPTMAPTRAB9AKDM4EROCK2 | |
| SCHEMBL6616574 | 0.87 | NR1H4 (0.42) | NAMPTMAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL6618762 | 0.87 | MAPT (0.49) | MAPTRAB9AKDM4EALDH1A1MEN1 | |
| SCHEMBL6616846 | 0.87 | NAMPT (0.42) | NAMPTMAPTROCK2ACKR3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |