Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922374 | 0.85 | CYP3A4 (0.49) | HTTHSD17B10KMT2AMEN1MAOA | |
| SCHEMBL6619999 | 0.85 | HSD17B10 (0.46) | HTTHSD17B10APLNRPTGS1AKR1C3 | |
| SCHEMBL4664847 | 0.81 | HSD17B10 (0.65) | HTTHSD17B10KMT2AMEN1POLB | |
| SCHEMBL8965127 | 0.81 | HTT (0.41) | HTTHSD17B10KMT2AMEN1APLNR | |
| SCHEMBL3027059 | 0.81 | APLNR (0.59) | HSD17B10KMT2AMEN1APLNRALDH1A1 | |
| SCHEMBL3918324 | 0.80 | ALDH1A1 (0.54) | HTTHSD17B10KMT2AMEN1APLNR | |
| SCHEMBL3127408 | 0.80 | ALDH1A1 (0.47) | HTTHSD17B10KMT2AMEN1APLNR | |
| SCHEMBL11295684 | 0.79 | GPR84 (0.47) | HTTKMT2AMEN1APLNRKDM1A | |
| SCHEMBL9917312 | 0.78 | KMT2A (0.48) | HTTKMT2AMEN1APLNRKDM1A | |
| SCHEMBL1690285 | 0.78 | HTT (0.46) | HTTHSD17B10KMT2AMEN1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418916-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |