Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616573 | 0.93 | NR1H4 (0.41) | NR1H4EPHX2MEN1KMT2ANAMPT | |
| SCHEMBL6618316 | 0.92 | MAPT (0.42) | NAMPTCTNNB1TCF7L2HTR1FHTR1A | |
| SCHEMBL6614876 | 0.91 | MEN1 (0.43) | NR1H4MEN1KMT2ANAMPTACKR3 | |
| SCHEMBL6617248 | 0.89 | NR1H4 (0.41) | NR1H4EPHX2MEN1KMT2ANAMPT | |
| SCHEMBL6618415 | 0.89 | MEN1 (0.44) | NR1H4EPHX2MEN1KMT2ANAMPT | |
| SCHEMBL6616947 | 0.89 | SSTR3 (0.43) | NAMPTCTNNB1TCF7L2 | |
| SCHEMBL6616422 | 0.88 | NAMPT (0.45) | NR1H4EPHX2NAMPTCTNNB1TCF7L2 | |
| SCHEMBL6621456 | 0.87 | MEN1 (0.44) | NR1H4MEN1KMT2ATRPV1CRACR2A | |
| SCHEMBL6615869 | 0.87 | NAMPT (0.41) | NR1H4EPHX2MEN1KMT2ANAMPT | |
| SCHEMBL6623315 | 0.87 | KCNK3 (0.43) | NR1H4MEN1KMT2ANAMPTACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |