Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614537 | 0.92 | ACKR3 (0.41) | MAPTTP53SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6615882 | 0.92 | NR1H4 (0.41) | CTNNB1TCF7L2ENPP2NAMPTHTR1F | |
| SCHEMBL6616947 | 0.90 | SSTR3 (0.43) | MAPTCTNNB1TCF7L2P2RY14NAMPT | |
| SCHEMBL6616422 | 0.90 | NAMPT (0.45) | CTNNB1TCF7L2NAMPT | |
| SCHEMBL6618133 | 0.90 | RAB9A (0.41) | MAPTTP53SMN1; SMN2CRACR2ARAB9A | |
| SCHEMBL6617319 | 0.88 | RAB9A (0.40) | MAPTTP53SMN1; SMN2NAMPTCRACR2A | |
| SCHEMBL6616244 | 0.88 | NAMPT (0.41) | MAPTTP53SMN1; SMN2NAMPTALDH1A1 | |
| SCHEMBL6616846 | 0.87 | NAMPT (0.42) | MAPTTP53SMN1; SMN2NAMPTLMNA | |
| SCHEMBL6619674 | 0.87 | NAMPT (0.43) | MAPTTP53NAMPTALDH1A1LMNA | |
| SCHEMBL6620121 | 0.86 | CASP3 (0.50) | MAPTTP53SMN1; SMN2NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |