Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616880 | 0.96 | MEN1 (0.43) | MEN1KMT2ATRPV1NPC1RAB9A | |
| SCHEMBL6610153 | 0.93 | MEN1 (0.41) | MEN1KMT2ATRPV1NPC1RAB9A | |
| SCHEMBL6618133 | 0.90 | RAB9A (0.41) | MEN1KMT2ATRPV1NPC1RAB9A | |
| SCHEMBL6620772 | 0.90 | MEN1 (0.40) | MEN1KMT2ATRPV1NPC1RAB9A | |
| SCHEMBL6618182 | 0.88 | MEN1 (0.43) | MEN1KMT2ATRPV1NPC1RAB9A | |
| SCHEMBL6616573 | 0.88 | NR1H4 (0.41) | MEN1KMT2ATRPV1NR1H4MAPK14 | |
| SCHEMBL6615259 | 0.88 | MEN1 (0.40) | MEN1KMT2ATRPV1NPC1RAB9A | |
| SCHEMBL6615882 | 0.87 | NR1H4 (0.41) | MEN1KMT2ATRPV1NR1H4CRACR2A | |
| SCHEMBL6618867 | 0.87 | TP53 (0.41) | MEN1KMT2ATRPV1SMN1; SMN2NR1H4 | |
| SCHEMBL6603511 | 0.86 | MEN1 (0.39) | MEN1KMT2ATRPV1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |