Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 8/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631633 | 0.88 | RAD52 (0.53) | PDPK1DAPK3PRKD3FLT1RPS6KA3 | |
| SCHEMBL6621186 | 0.88 | PDE10A (0.51) | PDPK1PDGFRBPDGFRAALDH1A1SMN1; SMN2 | |
| SCHEMBL6616039 | 0.86 | TDP1 (0.51) | PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6618226 | 0.85 | PDPK1 (0.54) | PDPK1DAPK3PRKD3FLT1RPS6KA3 | |
| SCHEMBL1132076 | 0.85 | TDP1 (0.50) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27751211 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL6617564 | 0.77 | PDGFRB (0.58) | PDPK1PDGFRBPDGFRA | |
| SCHEMBL8317211 | 0.76 | NQO2 (0.48) | PDGFRBPDGFRAALDH1A1GLAGAA | |
| SCHEMBL28281503 | 0.75 | PDE10A (0.54) | PDPK1PDGFRBPDGFRAALDH1A1MAPT | |
| SCHEMBL4745584 | 0.74 | ENPP1 (0.49) | PDPK1PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042294-B1 | HETEROCYCLIC CYTOTOXIC AGENTS | UNIV RUTGERS (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6486167-B1 | Heterocyclic cytotoxic agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-11-26 | — | — | US | disclosed |
| US-6140328-A | FOR TREATING TUMOR | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2000-10-31 | — | — | US | disclosed |
| EP-1042294-A1 | HETEROCYCLIC CYTOTOXIC AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031067-A1 | HETEROCYCLIC CYTOTOXIC AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-06-24 | — | — | WO | disclosed |