Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CASR | P41180 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PPIB | P23284 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576223 | 0.87 | NPC1 (0.71) | PKMNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL5759180 | 0.83 | ALDH1A1 (0.59) | SMN1; SMN2POLBALDH1A1MEN1KMT2A | |
| SCHEMBL4587584 | 0.83 | NPC1 (0.61) | PKMNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL3063620 | 0.82 | ALDH1A1 (0.76) | PKMPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL6616236 | 0.81 | RAB9A (0.66) | PKMNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL16562080 | 0.81 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2POLBCASR | |
| SCHEMBL5518470 | 0.81 | NPC1 (0.63) | PKMNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL4743993 | 0.80 | TGM2 (0.63) | PKMNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL27582701 | 0.80 | NPC1 (0.61) | PKMNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL17916794 | 0.80 | SMN1; SMN2 (0.88) | NPC1RAB9ASMN1; SMN2POLBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412338-A1 | 1,3,5-TRIAZINE-2,4,6-TRIONES, PREPARATION AND USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | Neurocrine Biosciences, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003011839-A1 | 1,3,5-TRIAZINE-2,4,6-TRIONES, PREPARATION AND USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2003-02-13 | — | — | WO | disclosed |