Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618436 | 0.92 | RAB9A (0.43) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6646084 | 0.90 | ACKR3 (0.41) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6618879 | 0.90 | SMN1; SMN2 (0.43) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6616601 | 0.89 | ACKR3 (0.48) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6618494 | 0.89 | ACKR3 (0.41) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6618286 | 0.87 | ACKR3 (0.42) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL6616478 | 0.87 | ACKR3 (0.44) | ALDH1A1RAB9ANPC1TP53MAPT | |
| SCHEMBL6620870 | 0.87 | MAPT (0.43) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL6617884 | 0.86 | ACKR3 (0.42) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL6618339 | 0.86 | ACKR3 (0.44) | ALDH1A1RAB9ANPC1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |