Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618339 | 0.98 | ACKR3 (0.44) | ACKR3NPC1RAB9AMAPTMEN1 | |
| SCHEMBL6618429 | 0.92 | ACKR3 (0.44) | ACKR3NPC1RAB9AMAPTMEN1 | |
| SCHEMBL6619166 | 0.92 | MAPT (0.44) | ACKR3NPC1RAB9AMAPTMEN1 | |
| SCHEMBL6621181 | 0.90 | LMNA (0.40) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6618981 | 0.89 | JAK2 (0.40) | ACKR3CNR1ITGB1ITGA4 | |
| SCHEMBL6618467 | 0.88 | RAB9A (0.39) | NPC1RAB9AMEN1KMT2ACNR1 | |
| SCHEMBL6619381 | 0.88 | HRH3 (0.43) | CNR1ITGB1ITGA4 | |
| SCHEMBL6616301 | 0.87 | ALDH1A1 (0.48) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6634119 | 0.86 | CNR1 (0.42) | NPC1RAB9AMAPTCNR1 | |
| SCHEMBL6617585 | 0.86 | ALDH1A1 (0.43) | ACKR3NPC1RAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |