Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.39 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618436 | 0.98 | RAB9A (0.43) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6616601 | 0.93 | ACKR3 (0.48) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6617884 | 0.92 | ACKR3 (0.42) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6618494 | 0.92 | ACKR3 (0.41) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6618286 | 0.91 | ACKR3 (0.42) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6646084 | 0.91 | ACKR3 (0.41) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6616301 | 0.90 | ALDH1A1 (0.48) | SMN1; SMN2RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL6617986 | 0.89 | MAPT (0.43) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6618279 | 0.88 | MAPK14 (0.41) | SMN1; SMN2RAB9ANPC1ACKR3ALDH1A1 | |
| SCHEMBL6613507 | 0.88 | MAPT (0.42) | SMN1; SMN2RAB9ANPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |