Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | AMPD3 | Q01432 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620085 | 0.85 | TDP1 (0.49) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL28774981 | 0.79 | MBOAT4 (0.48) | ALDH1A1TDP1KMT2AAMPD3MMP8 | |
| SCHEMBL1706652 | 0.77 | ALDH1A1 (0.60) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL23501489 | 0.76 | ALDH1A1 (0.58) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL19105239 | 0.76 | ALDH1A1 (0.58) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL522510 | 0.76 | ALDH1A1 (0.62) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL991531 | 0.76 | ALDH1A1 (0.62) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL2016291 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL12632940 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL12632939 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TDP1KMT2ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683781-B1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | METABASIS THERAPEUTICS INC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-5731432-A | Inhibitors of adenosine monophosphate deaminase | GENSIA SICOR INC. (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0683781-A4 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE. | GENSIA PHARMA (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0683781-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA PHARMACEUTICALS, INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018200-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |