Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.45 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.45 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645819 | 0.80 | NAMPT (0.48) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6614054 | 0.77 | NAMPT (0.55) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL4679762 | 0.77 | ABCC9 (0.56) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL4679754 | 0.77 | ABCC9 (0.56) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6645810 | 0.75 | NAMPT (0.50) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6614765 | 0.74 | NAMPT (0.55) | NAMPTNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL6612688 | 0.74 | CYP11B1 (0.54) | NAMPTNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL6669216 | 0.74 | RAB9A (0.47) | NAMPTNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL6642928 | 0.74 | RAB9A (0.47) | NAMPTNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL6614455 | 0.69 | ABCC9 (0.52) | NAMPTLMNAABCC9ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |