Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616620 | 0.80 | NAMPT (0.54) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6642934 | 0.74 | RAB9A (0.42) | NAMPTNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL6614054 | 0.73 | NAMPT (0.55) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL4679754 | 0.73 | ABCC9 (0.56) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL4679762 | 0.73 | ABCC9 (0.56) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6645810 | 0.71 | NAMPT (0.50) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL14082506 | 0.64 | NAMPT (0.86) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6648307 | 0.64 | ABCC9 (0.58) | NAMPTNPC1RAB9ALMNACYP11B1 | |
| SCHEMBL4683396 | 0.64 | ABCC9 (0.68) | NAMPTLMNACYP11B1CYP11B2ABCC9 | |
| SCHEMBL4683403 | 0.64 | ABCC9 (0.68) | NAMPTLMNACYP11B1CYP11B2ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |