Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14142880 | 0.91 | GRM7 (0.44) | PTGDR2GRM7NOS3NOS1NOS2 | |
| SCHEMBL3139821 | 0.86 | PTGDR2 (0.50) | PTGDR2NOS3NOS1NOS2MEN1 | |
| SCHEMBL20103281 | 0.81 | PTGDR2 (0.52) | PTGDR2NOS3NOS1NOS2MEN1 | |
| SCHEMBL4882683 | 0.81 | PTGDR2 (0.56) | PTGDR2NOS3NOS1NOS2MEN1 | |
| SCHEMBL14775521 | 0.80 | PTGDR2 (0.46) | PTGDR2MEN1KMT2AMAPT | |
| SCHEMBL19414348 | 0.79 | NOS3 (0.46) | PTGDR2GRM7NOS3NOS1NOS2 | |
| SCHEMBL21157883 | 0.79 | PTGDR2 (0.50) | PTGDR2NOS3NOS1NOS2MEN1 | |
| SCHEMBL27339809 | 0.79 | PTGDR2 (0.50) | PTGDR2NOS3NOS1NOS2MEN1 | |
| SCHEMBL11369877 | 0.78 | PTGDR2 (0.50) | PTGDR2NOS3NOS1NOS2MEN1 | |
| SCHEMBL4608591 | 0.77 | PTGDR2 (0.52) | PTGDR2NOS3NOS1NOS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418916-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |