Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.56 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608591 | 0.86 | PTGDR2 (0.52) | PTGDR2THRBMEN1KMT2AKDM4E | |
| SCHEMBL10597059 | 0.86 | THRB (0.58) | PTGDR2NUDT1BACE1HSP90AA1THRB | |
| SCHEMBL4609520 | 0.84 | PTGDR2 (0.50) | PTGDR2THRBMEN1KMT2AKDM4E | |
| SCHEMBL6616630 | 0.81 | PTGDR2 (0.54) | PTGDR2MEN1KMT2AALDH1A1MAPT | |
| Acetic Acid SCHEMBL27702447 | 0.80 | PTGDR2 (0.56) | PTGDR2THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL20103281 | 0.79 | PTGDR2 (0.52) | PTGDR2MEN1KMT2ANOS3NOS1 | |
| SCHEMBL21157883 | 0.77 | PTGDR2 (0.50) | PTGDR2THRBMEN1KMT2AKDM4E | |
| SCHEMBL27339809 | 0.77 | PTGDR2 (0.50) | PTGDR2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3139821 | 0.77 | PTGDR2 (0.50) | PTGDR2MEN1KMT2AALDH1A1NOS3 | |
| SCHEMBL11369877 | 0.77 | PTGDR2 (0.50) | PTGDR2MEN1KMT2ANOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4321257-A | Potentiated medicaments | JOHNSON & JOHNSON (US) | 1982-03-23 | — | — | US | claimed |
| US-20080269335-A1 | 2-(4-Chloro-2-cyclohexylphenoxy)propionic acid; (4-Bromo-2-cyclohexylphenoxy)propionic acid ethyl ester; ethyl-2-bromopropionate is reacted with 4-chloro-2-cyclohexylphenol in presence of cesium carbonate and N,N-dimethylfomamide; antiallergenic and antiinflammatory agent | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
| CN-1950323-A | CRTH2 receptor antagonists | NOVARTIS AG (CH) | 2007-04-18 | — | — | CN | disclosed |
| EP-1756032-A1 | CRTH2 RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105727-A1 | CRTH2 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2005-11-10 | — | — | WO | disclosed |
| US-4474748-A | ANTIBIOTICS, FUNGICIDES, ANTISEPTICS | JOHNSON & JOHNSON (US) | 1984-10-02 | — | — | US | disclosed |
| US-4321257-A | Potentiated medicaments | JOHNSON & JOHNSON (US) | 1982-03-23 | — | — | US | disclosed |
| US-4197318-A | CYCLOHEXYL SUBSTITUTED ALKANOLS AS POTENTIATORS | JOHNSON & JOHNSON (US) | 1980-04-08 | — | — | US | disclosed |
| US-4091090-A | PENETRANT ACCELERATOR COMPRISING CYCLOHEXYL-SUBSTITUTED ALKANOLS | JOHNSON & JOHNSON (US) | 1978-05-23 | — | — | US | disclosed |
| US-4006218-A | MICROBIOCIDE | JOHNSON & JOHNSON (US) | 1977-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269335-A1 | 2-(4-Chloro-2-cyclohexylphenoxy)propionic acid; (4-Bromo-2-cyclohexylphenoxy)propionic acid ethyl ester; ethyl-2-bromopropionate is reacted with 4-chloro-2-cyclohexylphenol in presence of cesium carbonate and N,N-dimethylfomamide; antiallergenic and antiinflammatory agent | EPX, NR3C2, FPR2 | PTGDR2 245/4885NUDT1 2958/4885BACE1 3746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.