Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619863 | 0.97 | RAB9A (0.43) | RAB9AALDH1A1MAPTPKMNPC1 | |
| SCHEMBL6618131 | 0.89 | MAPT (0.45) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL6617223 | 0.89 | MAPT (0.40) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL6614679 | 0.88 | MAPT (0.42) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL6647398 | 0.87 | KMT2A (0.38) | RAB9AMAPTKDM4EMEN1KMT2A | |
| SCHEMBL6603282 | 0.86 | CRACR2A (0.45) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL6651951 | 0.86 | P2RY14 (0.41) | MAPTSMN1; SMN2LMNAMAPK14HPGD | |
| SCHEMBL6622320 | 0.85 | MAPT (0.42) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL6618868 | 0.85 | RAB9A (0.45) | RAB9AALDH1A1MAPTPKMNPC1 | |
| SCHEMBL6615996 | 0.85 | HPGD (0.50) | RAB9AALDH1A1MAPTPKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |