Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | CHRNE | Q04844 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651075 | 0.93 | KMT2A (0.39) | KMT2AMEN1HTTKDM4ERAB9A | |
| SCHEMBL6620324 | 0.90 | NPY2R (0.36) | KMT2AMEN1KDM4EKCNJ6KCNJ5 | |
| SCHEMBL6603282 | 0.89 | CRACR2A (0.45) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL6651951 | 0.89 | P2RY14 (0.41) | MAPTPOLBNAMPTLMNA | |
| SCHEMBL6616726 | 0.88 | SLC1A2 (0.38) | KMT2AKDM4ERAB9APOLBNAMPT | |
| SCHEMBL6616552 | 0.88 | NPY2R (0.36) | KMT2AMEN1KDM4EKCNJ6KCNJ5 | |
| SCHEMBL6617721 | 0.87 | EPHX2 (0.39) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL6617188 | 0.87 | RAB9A (0.41) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL6618271 | 0.86 | MAPT (0.41) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL6617603 | 0.86 | CHRNE (0.45) | KMT2AMEN1MAPTKCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |