Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619198 | 0.91 | CRACR2A (0.44) | CRACR2AKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL6651951 | 0.89 | P2RY14 (0.41) | CRACR2ASMN1; SMN2MAPTHPGDPOLB | |
| SCHEMBL6647398 | 0.89 | KMT2A (0.38) | KMT2AMEN1MAPTRAB9AKDM4E | |
| SCHEMBL6616751 | 0.88 | CRACR2A (0.45) | CRACR2AKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL6615270 | 0.86 | CRACR2A (0.44) | CRACR2AKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL6620229 | 0.86 | PPARG (0.42) | CRACR2AKMT2AMEN1MAPTRAB9A | |
| SCHEMBL6620569 | 0.86 | CNR1 (0.41) | CRACR2AKMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL6617188 | 0.86 | RAB9A (0.41) | KMT2AMEN1SMN1; SMN2MAPTHPGD | |
| SCHEMBL6620324 | 0.85 | NPY2R (0.36) | KMT2AMEN1KDM4E | |
| SCHEMBL6616443 | 0.85 | CRACR2A (0.42) | CRACR2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |