Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8110669 | 1.00 | NOS1 (0.43) | NOS1MEN1KMT2AHSP90AA1IDO1 | |
| SCHEMBL6621659 | 1.00 | NOS1 (0.43) | NOS1MEN1KMT2AHSP90AA1IDO1 | |
| SCHEMBL6621847 | 0.83 | TRPA1 (0.55) | MEN1KMT2AHSP90AA1IDO1CDK2 | |
| SCHEMBL8110919 | 0.83 | TRPA1 (0.55) | MEN1KMT2AHSP90AA1IDO1CDK2 | |
| SCHEMBL6618925 | 0.83 | TRPA1 (0.55) | MEN1KMT2AHSP90AA1IDO1CDK2 | |
| SCHEMBL6616738 | 0.79 | SMN1; SMN2 (0.58) | CDK2MAPK1GSK3BCDK5CDK5R1 | |
| SCHEMBL6623309 | 0.77 | MAPK1 (0.53) | NOS1CDK2TRPA1MAPK1GSK3B | |
| SCHEMBL6620107 | 0.77 | MAPK1 (0.53) | NOS1CDK2TRPA1MAPK1GSK3B | |
| SCHEMBL6616315 | 0.77 | CYP1A2 (0.46) | KMT2AHSP90AA1IDO1CDK2TGFBR1 | |
| SCHEMBL6617020 | 0.77 | CYP1A2 (0.46) | KMT2AHSP90AA1IDO1CDK2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |