Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ADH5 | P11766 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617400 | 0.78 | NCOA3 (0.36) | CRBNIDO1CYP3A4CYP2D6ALDH1A1 | |
| Water SCHEMBL6553144 | 0.74 | CYP3A4 (0.36) | CRBNIDO1NOTUMCYP3A4CYP2D6 | |
| SCHEMBL7950943 | 0.73 | CRBN (0.33) | CRBNIDO1NOTUMCYP3A4CYP2D6 | |
| SCHEMBL6618970 | 0.72 | CRBN (0.36) | CRBNIDO1NOTUMCA12CA9 | |
| SCHEMBL8625833 | 0.71 | LMNA (0.56) | CYP3A4CYP2D6ALDH1A1LMNACYP1A2 | |
| SCHEMBL7952055 | 0.68 | ALDH1A1 (0.42) | CRBNCYP3A4CYP2D6ALDH1A1LMNA | |
| SCHEMBL4262382 | 0.63 | ALDH1A1 (0.35) | CYP3A4CYP2D6ALDH1A1LMNACYP1A2 | |
| SCHEMBL6619504 | 0.62 | ALDH1A1 (0.35) | CYP3A4CYP2D6ALDH1A1LMNACYP1A2 | |
| SCHEMBL4260435 | 0.62 | CXCR2 (0.35) | CYP3A4CYP2D6ALDH1A1LMNACYP1A2 | |
| SCHEMBL6622188 | 0.61 | CXCR2 (0.41) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877748-B1 | PYRIDO-1,2,4-THIADIAZINE AND PYRIDO-1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | UNIV LIEGE (BE) | 2004-11-03 | — | — | EP | disclosed |
| CN-1208418-A | Pyrido-1, 2, 4-thiadiazine and pyrido-1, 4-thiazine derivatives, preparation method and application thereof | NOVO NORDISK AS (DK) | 1999-02-17 | — | — | CN | disclosed |
| EP-0877748-A1 | PYRIDO-1,2,4-THIADIAZINE AND PYRIDO-1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-11-18 | — | — | EP | disclosed |
| US-5792764-A | ENDOCRINE DISORDERS ESPECIALLY AS A K(ATP)-CHANNEL MODULATOR | NOVO NORDISK A/S (DK) | 1998-08-11 | — | — | US | disclosed |
| WO-1997026264-A1 | PYRIDO-1,2,4-THIADIAZINE AND PYRIDO-1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-07-24 | — | — | WO | disclosed |