Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 12/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286626 | 0.83 | CA12 (0.45) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4262382 | 0.75 | ALDH1A1 (0.35) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8286616 | 0.73 | CA12 (0.45) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4260435 | 0.73 | CXCR2 (0.35) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Diazoxide SCHEMBL41255 | 0.72 | ABCC8 (1.00) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6619132 | 0.71 | GPR84 (0.35) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6617789 | 0.71 | GPR84 (0.35) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6617261 | 0.71 | CRBN (0.38) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6619504 | 0.71 | ALDH1A1 (0.35) | LMNAALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6616646 | 0.70 | CXCR2 (0.40) | LMNACXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |