Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616388 | 0.97 | NAMPT (0.37) | NAMPTDRD2ASAH1LMNAHTT | |
| SCHEMBL6618192 | 0.92 | NAMPT (0.36) | NAMPTDRD2ASAH1LMNAHTT | |
| SCHEMBL6621562 | 0.91 | CNR1 (0.39) | NAMPTDRD2LMNAHTTNPSR1 | |
| SCHEMBL6617920 | 0.91 | KMT2A (0.40) | DRD2LMNAHSD17B10MAPTKCNJ6 | |
| SCHEMBL6617610 | 0.89 | KMT2A (0.40) | ASAH1LMNAROCK2FAAHMAPT | |
| SCHEMBL6617829 | 0.88 | ALDH1A1 (0.39) | DRD2LMNAHTTNPSR1KCNB1 | |
| SCHEMBL6618373 | 0.87 | NPC1 (0.39) | DRD2LMNAMAPTKMT2A | |
| SCHEMBL6617082 | 0.87 | TERT (0.36) | DRD2ASAH1LMNAROCK2KMT2A | |
| SCHEMBL6615563 | 0.87 | TERT (0.36) | DRD2ASAH1LMNAROCK2MAPT | |
| SCHEMBL6616878 | 0.87 | KMT2A (0.38) | ASAH1LMNAROCK2FAAHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |