Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616321 | 0.95 | CHRNE (0.38) | ANPEPEPHX2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6617613 | 0.91 | NAMPT (0.38) | KCNJ6KCNJ5KCNJ3NAMPTLMNA | |
| SCHEMBL6618534 | 0.89 | NPY2R (0.38) | CNR1ANPEPEPHX2KCNJ6KCNJ5 | |
| SCHEMBL6616388 | 0.88 | NAMPT (0.37) | NAMPTLMNAHTTNPSR1DRD2 | |
| SCHEMBL6603139 | 0.87 | BRAF (0.40) | CNR1EPHX2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6617100 | 0.87 | NPC1 (0.40) | FPR1MAPK1DRD2ADRA1AMAPT | |
| SCHEMBL6617829 | 0.87 | ALDH1A1 (0.39) | S1PR3LMNAHTTNPSR1DRD2 | |
| SCHEMBL6617462 | 0.87 | CNR1 (0.39) | CNR1ANPEPEPHX2NAMPTMAPK1 | |
| SCHEMBL6617294 | 0.86 | SLC1A2 (0.39) | CNR1NAMPTFPR1MAPK1DRD2 | |
| SCHEMBL6617920 | 0.86 | KMT2A (0.40) | EPHX2KCNJ6KCNJ5KCNJ3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |