Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.45 |
| ▸ | MMP9 | P14780 | 4/20 | 0.45 |
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP3 | P08254 | 4/20 | 0.44 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618902 | 0.90 | KLK5 (0.46) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7563179 | 0.84 | HTT (0.43) | MMP1MMP9MMP13MMP2CA2 | |
| SCHEMBL4863780 | 0.81 | KLK5 (0.45) | MMP1MMP9MMP13 | |
| SCHEMBL6617093 | 0.79 | ATM (0.43) | CTSD | |
| SCHEMBL7562033 | 0.77 | REN (0.46) | MMP1MMP9MMP13 | |
| SCHEMBL5772204 | 0.75 | MMP1 (0.38) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL6617625 | 0.73 | MMP2 (0.52) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL1601535 | 0.73 | HTT (0.37) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7587059 | 0.72 | MLNR (0.45) | CTSD | |
| SCHEMBL1602562 | 0.72 | HTT (0.37) | MMP1MMP9MMP13MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086076-B1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2004-12-22 | — | — | EP | disclosed |