Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.38 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.37 |
| ▸ | CHRNE | Q04844 | 2/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618271 | 0.90 | MAPT (0.41) | RAB9AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL6630940 | 0.89 | KMT2A (0.41) | EPHX2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL6618495 | 0.88 | GNRHR (0.40) | EPHX2RAB9AKDM4EKMT2AMAPT | |
| SCHEMBL6619186 | 0.88 | MEN1 (0.38) | EPHX2RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL6617729 | 0.88 | EPHX2 (0.37) | EPHX2RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL6647398 | 0.87 | KMT2A (0.38) | RAB9AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL6618884 | 0.86 | POLB (0.42) | RAB9AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL6620229 | 0.86 | PPARG (0.42) | EPHX2RAB9AMEN1KMT2AMAPT | |
| SCHEMBL6615628 | 0.86 | KDM4C (0.44) | RAB9AKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL6623103 | 0.86 | MAPK14 (0.40) | EPHX2RAB9AMAPTNPC1CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |