Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CRACR2A | Q9BSW2 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617068 | 0.94 | PKM (0.38) | TP53MAPTNPC1RAB9AGRM4 | |
| SCHEMBL6619198 | 0.92 | CRACR2A (0.44) | PPARGCRACR2ATP53MAPTDDB1 | |
| SCHEMBL6618455 | 0.89 | LMNA (0.39) | CRACR2AMAPTGRM4CHRM5CHRM1 | |
| SCHEMBL6621042 | 0.89 | ACKR3 (0.40) | PPARGGRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL6618495 | 0.88 | GNRHR (0.40) | TP53MAPTNPC1RAB9AEPHX2 | |
| SCHEMBL6614830 | 0.88 | MAPT (0.41) | PPARGCRACR2AMAPTNPC1RAB9A | |
| SCHEMBL6617159 | 0.88 | JAK2 (0.38) | PPARGCRACR2ATP53NPC1RAB9A | |
| SCHEMBL6618849 | 0.88 | CHRM5 (0.40) | CRACR2ATP53MAPTNPC1RAB9A | |
| SCHEMBL6617337 | 0.87 | CNR1 (0.39) | TP53MAPTRAB9ACHRM5CHRM1 | |
| SCHEMBL6603910 | 0.87 | NAMPT (0.42) | CRACR2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |