Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | GCGR | P47871 | 4/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | GIPR | P48546 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 6/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616422 | 0.87 | NAMPT (0.45) | NAMPTGCGRDDR1DDR2GIPR | |
| SCHEMBL6615941 | 0.85 | GCGR (0.37) | GCGRDDR1DDR2GIPRABL1 | |
| SCHEMBL6614050 | 0.84 | GCGR (0.43) | NAMPTGCGRGIPRABL1CTNNB1 | |
| SCHEMBL6619674 | 0.82 | NAMPT (0.43) | NAMPTSLC2A1 | |
| SCHEMBL6619980 | 0.81 | GCGR (0.45) | NAMPTGCGRGIPRABL1SLC2A1 | |
| SCHEMBL6615997 | 0.81 | GCGR (0.45) | NAMPTGCGRGIPRABL1CTNNB1 | |
| SCHEMBL6651122 | 0.81 | NAMPT (0.40) | NAMPTGCGRDDR1DDR2GIPR | |
| SCHEMBL6617661 | 0.81 | GCGR (0.41) | NAMPTGCGRGIPRABL1CTNNB1 | |
| SCHEMBL6619043 | 0.80 | SLC2A1 (0.42) | NAMPTGCGRGIPRABL1SLC2A1 | |
| SCHEMBL6616710 | 0.80 | ABL1 (0.35) | NAMPTGCGRDDR1DDR2GIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |