Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661793 | 1.00 | PREP (0.39) | PREPCA12CA1CA9HSP90AA1 | |
| SCHEMBL717551 | 0.81 | CA12 (0.41) | PREPCA12CA1CA9HSP90AA1 | |
| SCHEMBL1518401 | 0.79 | CYP1A1 (0.48) | — | |
| SCHEMBL1518402 | 0.79 | CYP1A1 (0.48) | — | |
| SCHEMBL3544897 | 0.78 | CYP1A1 (0.42) | PREPCA12CA1CA9HSP90AA1 | |
| SCHEMBL3542553 | 0.76 | CA12 (0.39) | PREPCA12CA1CA9HSP90AA1 | |
| SCHEMBL662931 | 0.75 | ALDH1A1 (0.40) | PREP | |
| SCHEMBL662930 | 0.75 | ALDH1A1 (0.40) | PREP | |
| SCHEMBL1417191 | 0.75 | CA12 (0.38) | PREPCA12CA1CA9HSP90AA1 | |
| SCHEMBL29520875 | 0.75 | CA12 (0.38) | PREPCA12CA1CA9HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343968-B2 | Case of renin inhibitors | MERCK CANADA INC. (CA) | 2013-01-01 | — | — | US | disclosed |
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8076359-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-12-13 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| EP-2097377-B1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2010-07-07 | — | — | EP | disclosed |
| US-20100120859-A1 | NOVEL CASE OF RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-05-13 | — | — | US | disclosed |
| US-20100063091-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-03-11 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063091-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | PREP 7/4885CA12 4656/4885CA1 4602/4885 |
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | PREP 26/4885CA12 4300/4885CA1 4412/4885 |
| US-20100120859-A1 | NOVEL CASE OF RENIN INHIBITORS | REN, ACE, AGTR1 | PREP 10/4885CA12 2721/4885CA1 2121/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | PREP 23/4885CA12 4446/4885CA1 4390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.