Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 15/20 | 0.48 |
| ▸ | NPC1 | O15118 | 13/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.43 |
| ▸ | TP53 | P04637 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616979 | 0.95 | RAB9A (0.47) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6618189 | 0.94 | RAB9A (0.47) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6615538 | 0.91 | RAB9A (0.48) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6619931 | 0.89 | MAPT (0.46) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6619775 | 0.88 | RAB9A (0.46) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6617830 | 0.88 | RAB9A (0.43) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6616612 | 0.84 | RAB9A (0.47) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6617632 | 0.83 | MAPT (0.47) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6618509 | 0.82 | MAPT (0.44) | RAB9ANPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL6631790 | 0.81 | ALDH1A1 (0.47) | RAB9ANPC1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |