Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618249 | 0.94 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6615112 | 0.90 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6629335 | 0.87 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6628153 | 0.86 | RAB9A (0.48) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6616753 | 0.84 | KDM5A (0.43) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6620081 | 0.83 | KMT2A (0.43) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6616287 | 0.82 | KDM5A (0.43) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6612239 | 0.81 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL6618107 | 0.81 | RAB9A (0.48) | ALDH1A1KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6616472 | 0.81 | NPC1 (0.47) | ALDH1A1KDM4EHPGDHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |