Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 16/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 16/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615961 | 0.91 | MCHR1 (0.45) | ADRA2ANPY5RMCHR1HTR1AADRA1A | |
| SCHEMBL6603635 | 0.86 | ACACB (0.53) | ADRA2ANPY5RMCHR1ACACBACACA | |
| SCHEMBL6630745 | 0.86 | CFD (0.45) | NPY5RACACBACACAALDH1A1 | |
| SCHEMBL3947714 | 0.85 | MCHR1 (0.58) | ADRA2ANPY5RMCHR1HTR1AADRA1A | |
| SCHEMBL3947716 | 0.85 | MCHR1 (0.58) | ADRA2ANPY5RMCHR1HTR1AADRA1A | |
| SCHEMBL6930461 | 0.81 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL3937500 | 0.80 | MCHR1 (0.54) | ADRA2ANPY5RMCHR1HTR1AADRA1A | |
| SCHEMBL3945735 | 0.80 | MCHR1 (0.54) | ADRA2ANPY5RMCHR1HTR1AADRA1A | |
| SCHEMBL4036188 | 0.79 | MCHR1 (0.62) | ADRA2ANPY5RMCHR1HTR1AADRA1A | |
| SCHEMBL4036192 | 0.79 | MCHR1 (0.62) | ADRA2ANPY5RMCHR1HTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432693-A2 | MCH RECEPTOR ANTAGONISTS | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028641-A2 | MCH RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2003-04-10 | — | — | WO | disclosed |