Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323447 | 0.93 | EPHX2 (0.45) | GABRA1GABRA5CD274MAPK1POLB | |
| SCHEMBL6316178 | 0.89 | GABRA1 (0.47) | GABRA1GABRA5CD274MAPK1LMNA | |
| SCHEMBL6324006 | 0.85 | MAPT (0.48) | CD274LMNARAB9A | |
| SCHEMBL6321552 | 0.84 | MAPK1 (0.52) | GABRA1MAPK1POLBLMNARAB9A | |
| SCHEMBL6317605 | 0.83 | L3MBTL1 (0.57) | GABRA5 | |
| SCHEMBL6617642 | 0.83 | ALDH1A1 (0.48) | RIPK1LMNA | |
| SCHEMBL6324039 | 0.83 | ALDH1A1 (0.52) | GABRA1MAPK1LMNARAB9A | |
| SCHEMBL6315938 | 0.83 | GABRA1 (0.45) | GABRA1GABRA5MAPK1POLBLMNA | |
| SCHEMBL6323900 | 0.83 | GABRA1 (0.51) | GABRA1GABRA5CD274MAPK1POLB | |
| SCHEMBL6324304 | 0.83 | L3MBTL1 (0.53) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | claimed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | claimed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |