Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 15/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322933 | 0.84 | CA12 (0.47) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL18329438 | 0.81 | CA12 (0.50) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL17166118 | 0.80 | CA12 (0.48) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL19497046 | 0.80 | BDKRB1 (0.49) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL1070351 | 0.77 | CA12 (0.61) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL6621914 | 0.75 | ALDH1A1 (0.64) | CA1CA2CA9KMT2A | |
| SCHEMBL29026652 | 0.75 | BDKRB1 (0.47) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL22445329 | 0.75 | BDKRB1 (0.44) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL10561912 | 0.74 | CA12 (0.46) | HDAC1HDAC6CA12CA1CA2 | |
| SCHEMBL27859776 | 0.74 | HDAC1 (0.46) | HDAC1HDAC6BDKRB1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683781-B1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | METABASIS THERAPEUTICS INC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-5731432-A | Inhibitors of adenosine monophosphate deaminase | GENSIA SICOR INC. (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0683781-A4 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE. | GENSIA PHARMA (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0683781-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA PHARMACEUTICALS, INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018200-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |