Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 11/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308650 | 0.86 | KIF11 (0.50) | ADORA2AADORA2BMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL1145076 | 0.82 | MAP2K4 (0.57) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL31504557 | 0.82 | MAP2K4 (0.57) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL23559721 | 0.81 | MAP2K4 (0.58) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL4403122 | 0.78 | MAPK1 (0.43) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL4137054 | 0.78 | MAPK1 (0.43) | ADORA2AADORA2BMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL1501529 | 0.78 | KDM4E (0.55) | MAP2K4 | |
| SCHEMBL14129804 | 0.78 | KDM4E (0.45) | ADORA2AADORA2BMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL4780688 | 0.77 | JAK2 (0.50) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL23062796 | 0.77 | MAP2K4 (0.53) | ADORA2AADORA2BMAPK1MAP2K4MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418916-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |