Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DBH | P09172 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 15/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 7/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31504557 | 0.82 | MAP2K4 (0.57) | KDM4ERECQLMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL1145076 | 0.82 | MAP2K4 (0.57) | KDM4ERECQLMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL16308650 | 0.82 | KIF11 (0.50) | KDM4EMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL23559721 | 0.81 | MAP2K4 (0.58) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL6618549 | 0.78 | ADORA2A (0.43) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL4137054 | 0.78 | MAPK1 (0.43) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL4403122 | 0.78 | MAPK1 (0.43) | KDM4EMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL1501529 | 0.78 | KDM4E (0.55) | KDM4EMAP2K4DYRK1A | |
| SCHEMBL4780688 | 0.77 | JAK2 (0.50) | KDM4EGAAMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL24814135 | 0.75 | ABL1 (0.48) | KDM4EDBHGAARECQLJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846742-B2 | Neuronal pain pathway modulators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-09-30 | — | — | US | disclosed |
| US-20080176920-A1 | protein kinase G inhibitors; analogs of balanol | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176920-A1 | protein kinase G inhibitors; analogs of balanol | PRKCG, GRK3, PRKG1 | KDM4E 2960/4885DBH 1321/4885GAA 1689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.