SCHEMBL6618630

SCHEMBL6618630

CCCCCOc1ccc2nc(-c3cccnc3)n(-c3ccc(F)cc3)c2c1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 8/20 0.52
CYP11B1 P15538 6/20 0.52
AOC3 Q16853 6/20 0.47
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP19A1 P11511 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
AOC2 O75106 1/20 0.44
G6PD P11413 1/20 0.43
HRH3 Q9Y5N1 1/20 0.42
PDE2A O00408 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6618975 0.92 CYP19A1 (0.48) CYP11B2CYP11B1AOC3CYP3A4CYP2D6
SCHEMBL6619017 0.91 CYP19A1 (0.47) CYP11B2CYP11B1AOC3CYP3A4CYP2D6
SCHEMBL1378188 0.87 CYP11B2 (0.46) CYP11B2CYP11B1AOC3AOC2G6PD
SCHEMBL2214832 0.87 CYP11B2 (0.46) CYP11B2CYP11B1AOC3G6PDPDE2A
SCHEMBL2213278 0.86 CYP11B2 (0.45) CYP11B2CYP11B1AOC3AOC2G6PD
SCHEMBL2215534 0.86 CYP11B2 (0.46) CYP11B2CYP11B1AOC3G6PDHRH3
SCHEMBL2215667 0.85 CYP11B2 (0.60) CYP11B2CYP11B1AOC3CYP19A1AOC2
SCHEMBL2212913 0.80 ALDH1A1 (0.44) CYP11B2CYP11B1AOC3G6PDHRH3
SCHEMBL2211748 0.80 PPARG (0.47) CYP11B2CYP11B1AOC3G6PDHRH3
SCHEMBL7717836 0.80 PDE10A (0.51) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1474415-A1 1-PHENYL-2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, THE USE THEREOF FOR PRODUCING DRUGS USED IN THE TREATMENT OF IMMUNOLOGICAL DISEASES Schering Aktiengesellschaft (DE) 2004-11-10 EP disclosed
WO-2003068766-A1 1-PHENYL-2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, THE USE THEREOF FOR PRODUCING DRUGS USED IN THE TREATMENT OF IMMUNOLOGICAL DISEASES SCHERING AKTIENGESELLSCHAFT (DE) 2003-08-21 WO disclosed